Showing posts with label brain. Show all posts
Showing posts with label brain. Show all posts
February 28, 2018

Discovery of brain region that can ease pain paves way for non-opioid painkillers

by , in
A new understanding into how our brain modulates pain signals could lead to a new generation...
A new understanding into how our brain modulates pain signals could lead to a new generation of non-opioid painkillers(Credit: lightsource/Depositphotos)
Pain is an important biological mechanism. It tells us when something in our body is damaged, and forces us into inactivity so energy can be diverted to healing. But sometimes pain can be counter-effective, hindering a person's ability to actively help themselves, so the brain effectively "turns down" those pain signals so relief can be effectively found. New research has identified where in the brain this natural painkilling system is controlled from, suggesting new pathways toward non-opioid painkillers. 
In 2017, the US Department of Health and Human Services declared the ongoing opioid crisis in the country as a public health emergency. The rate of opioid overdose deaths in 2016 were five times higher than in 1999. Research into alternative methods of pain control has never been more important than right now and scientists are investigating a variety of different targets, from tricking the body's pain-signaling pathways at the site of an injury to studying people with unique genetic mutations that make them feel no pain. 
This new research, led by scientists at the University of Cambridge, set out to understand how the brain actively regulates pain in the body through the endogenous analgesia system that can seemingly "turn down" pain signals. The team devised a pair of experiments designed to home in on the parts of the brain that modulate the degree of pain felt throughout the body. 
"We're trying to understand exactly what the endogenous analgesia system is: why we have it, how it works and where it is controlled in the brain," says Ben Seymour, lead on the research project.
The first experiment subjected volunteers to an external source of painful heat on their arm that could be reduced by playing a game that led them to press a specific button. The degree of difficulty in the game varied and the volunteers constantly rated their pain levels while having their brain activity monitored. 
The fascinating results revealed that pain levels were identified as lower when a subject was actively working to target the right button, but pain was not reduced when the subject knew which button to press. This meant that a part of the brain was modulating the degree of pain felt depending on how actively the person was working on finding a solution to reducing the source of the pain. 
The subsequent experiment was to find where exactly in the brain this pain-modulating signal was coming from. A very specific target was identified in a small part of the prefrontal cortex – the pregenual cingulate cortex. 
"These results build a picture of why and how the brain decides to turn off pain in certain circumstances, and identify the pregenual cingulate cortex as a critical 'decision centre' controlling pain in the brain," says Seymour. 
The exciting conclusion is that this area of the brain could actively reduce the sensation of pain temporarily in situations where that pain is hindering a person from successfully doing something that could help. Future research will look at what inputs are activating this brain region and whether there are ways to artificially stimulate it, in the hopes of developing a new treatment for patients with chronic pain.
"If we can figure this out, it could lead to treatments that are much more selective in terms of how they treat pain," adds Seymour.
The research was published in the journal eLife.
February 23, 2018

How brain scans can read your mind to reconstruct the face you're thinking of

by , in
Neuroscientists have developed a system that can digitally recreate images seen through someone's eyes, like faces, from an EEG brain scan(Credit: University of Toronto Scarborough)
It's frustrating to have a clear mental image of something but not be able to exactly get it across in words or a drawing. Now, a team of neuroscientists from the University of Toronto Scarborough has developed a way to digitally recreate exactly the image someone is thinking about, by scanning their brain.
So-called mind-reading technology is getting eerily accurate. Along with allowing people to control prosthetics with their thoughts, these systems have quickly advanced from picking out what number you're thinking of to decoding more complex concepts. It's all happening so fast that some researchers have proposed new human rights regarding how the brain can be read or manipulated.
The new study was designed to see whether specific images could be plucked out of a person's mind. To test out the idea, the team hooked people up to electroencephalography (EEG) equipment and then showed them pictures of faces on a computer screen. The EEG system recorded their brain waves, and after running the data through machine learning algorithms the system was able to digitally recreate the face that the test subject had just seen.
"When we see something, our brain creates a mental percept, which is essentially a mental impression of that thing," says Dan Nemrodov, co-author of the study. "We were able to capture this percept using EEG to get a direct illustration of what's happening in the brain during this process."
Dan Nemrodov (left) and Adrian Nestor (middle), with one of the study participants in an EEG...
Brain-reading studies generally involve one of two methods – EEG and functional magnetic resonance imaging (fMRI). The former measures the electrical activity in the brain through a cap full of electrodes, while fMRI uses a magnetic field to monitor blood flow in different parts of the brain. Both have their advantages and disadvantages, but EEG is more commonly used, less expensive, and can record faster changes.
"fMRI captures activity at the time scale of seconds, but EEG captures activity at the millisecond scale," says Nemrodov. "So we can see with very fine detail how the percept of a face develops in our brain using EEG."
That high time accuracy allowed the team to determine that it only takes about 170 milliseconds for the human brain to create a decent mental picture of a face it's looking at.
In future, the team wants to expand the technique to be able to recreate objects other than faces, and do so over longer periods of time, allowing virtual reconstruction of images that a person remembers seeing more than a few seconds ago.
"It could provide a means of communication for people who are unable to verbally communicate," says Adrian Nestor, co-author of the study. "Not only could it produce a neural-based reconstruction of what a person is perceiving, but also of what they remember and imagine, of what they want to express. It could also have forensic uses for law enforcement in gathering eyewitness information on potential suspects rather than relying on verbal descriptions provided to a sketch artist."
February 14, 2018

Brain scans show why people get aggressive after a drink or two

by , in
An Australian study has shed light on the neural basis of alcohol-related aggression
An Australian study has shed light on the neural basis of alcohol-related aggression(Credit:Dmyrto_Z/Depositphotos)
It's common knowledge that a drink or two can lower inhibitions and result in people becoming aggressive and violent. Researchers from the University of New South Wales in Australia are asking why, using MRI scans to trace which part of the brain controls aggression.
The study involved 50 otherwise healthy male participants, who were given either a low dose of vodka or two glasses of a non-alcoholic placebo drink. Then using the Taylor Aggression Paradigm, a competitive reaction time task that has been used for the past 50 years to test aggression, the researchers used MRI scanner to identify which areas of the brain lit up when they behaved aggressively.
They found that participants who drank alcohol showed a temporary decrease in activity in the prefrontal cortex, a part of the brain which is believed to regulate aggressive behavior.
"Although there was an overall dampening effect of alcohol on the prefrontal cortex, even at a low dose of alcohol we observed a significant positive relationship between dorsomedial and dorsolateral prefrontal cortex activity and alcohol-related aggression," says Thomas Denson, lead author of the study. "These regions may support different behaviors, such as peace versus aggression, depending on whether a person is sober or intoxicated."
The alcohol was also found to decrease reward activation in the brain, reducing activity in the ventral striatum and the caudate, while the hippocampus, which is associated with memory, showed an increase in activity.
The research builds on existing theories on alcohol-related aggression, including another study that used neural imaging to show changes in the prefrontal cortex and the ventral striatum.
"We encourage future, larger-scale investigations into the neural underpinnings of alcohol-related aggression with stronger doses and clinical samples. Doing so could eventually substantially reduce alcohol-related harm," says Denson.
The team's study was published in Cognitive, Affective & Behavioral Neuroscience.
February 08, 2018

Dim light may be shrinking your brain

by , in

In lab rat tests, prolonged exposure to dim light caused the capacity of the hippocampus to diminish(Credit: londondeposit/Depositphotos)
If you've opted to go for low "mood lighting" in your office, you might want to think again. According to a new study from Michigan State University, when rats are exposed to dim lighting for prolonged periods, their brain capacity diminishes. The same could likely be true for humans.
The rodents used in the study were Nile grass rats, which are diurnal – that means they sleep at night and are active during the day.
When a group of the animals were exposed to dim light during the day for a period of four weeks, they lost about 30 percent of the capacity in their hippocampus, which is a part of the brain associated with learning and memory. They thus performed poorly on a spatial task that they had learned and performed previously.
Another group of rats had been exposed to bright light every day for four weeks, and their performance on that same task improved after that time. Additionally, the performance and brain capacity of the dim-light rats recovered fully, after they were given a break for one month and then subjected to four weeks of bright light.
It was found that sustained exposure to dim light led to a marked reduction in brain derived neurotrophic factor, which is a peptide that maintains healthy connections and neurons in the hippocampus. The dim light also caused a reduction in dendritic spines, which are the connections that allow neurons to communicate with one another.
Because light doesn't affect the hippocampus directly, the scientists believe that it must first be acting on other parts of the brain, after passing through the eyes. One area that's a possibility is a group of neurons within the hypothalamus, which produce a peptide known as orexin. That peptide, in turn, is known to influence a variety of brain functions.
Given this fact, the researchers wonder if giving orexin to the dim-light rats would have the same affect as exposing them to bright light. If it does, then it could have implications for people such as the elderly, or those who have eye problems.
"For people with eye disease who don't receive much light, can we directly manipulate this group of neurons in the brain, bypassing the eye, and provide them with the same benefits of bright light exposure?" asks Lily Yan, who worked on the project along with Antonio "Tony" Nunez and Joel Soler. "Another possibility is improving the cognitive function in the aging population and those with neurological disorders. Can we help them recover from the impairment or prevent further decline?".
February 08, 2018

Artificial synapses fill the gaps for brainier computer chips

by , in
An MIT team has developed a new kind of artificial synapse, enabling more brain-like computer chips(Credit: agsandrew/Depositphotos)
Right now, you're carrying around the most powerful computer in existence – the human brain. This naturally super-efficient machine is far better than anything humans have ever built, so it's not surprising that scientists are trying to reverse-engineer it. Rather than binary bits of information, neuromorphic computers are built with networks of artificial neurons, and now an MIT team has developed a more lifelike synapse to better connect those neurons.
For simplicity's sake, computers process and store information in a binary manner – everything can be broken down into a series of ones and zeroes. This system has served us well for the better part of a century, but having access to a whole new world of analog "grey areas" in between could really give computing power a shot in the arm.
The brain is a perfect model for those kinds of systems. While we've barely scratched the surface of how it works exactly, what we do know is that the brain deals with both analog and digital signals, processes and stores information in the same regions, and performs many operations in parallel. This is thanks to around 100 billion neurons dynamically communicating with each other via some 100 trillion synapses.
While neural networks mimic human thinking on the software side, neuromorphic chips are much more brain-like in the design of their hardware. Their architecture is made up of artificial neurons that process data and communicate with each other through artificial synapses. IBM's TrueNorth supercomputer is one of the most powerful neuromorphic systems, and Intel has recently unveiled a more modest, research-focused chip it calls Loihi.
In conventional neuromorphic chips, synapses are made of amorphous materials wedged in between the conductive layers of neighboring neurons. Ions flow through this material when a voltage is applied, transferring data between neurons. The problem is they can be unpredictable, with defects in the switching medium sending ions wandering off in different directions.
 "Once you apply some voltage to represent some data with your artificial neuron, you have to erase and be able to write it again in the exact same way," says Jeehwan Kim, lead researcher on the project. "But in an amorphous solid, when you write again, the ions go in different directions because there are lots of defects. This stream is changing, and it's hard to control. That's the biggest problem – nonuniformity of the artificial synapse."
To combat the problem, the MIT researchers designed a new medium for an artificial synapse. They started with a wafer of single-crystalline silicon, then grew a layer of silicon germanium over the top. Both materials have a lattice-like pattern, but silicon germanium's pattern is slightly larger, so when the two overlap it forms a kind of funnel shape, keeping ions on the straight and narrow.
The team built a neuromorphic chip using this technique, with silicon germanium synapses measuring about 25 nanometers wide. The team then tested them all by applying a voltage to them, and found that overall there was about a four percent variation in the current that passed through them. An individual synapse, tested over 700 cycles, was also found to keep a consistent current, with a variation of just 1 percent.
"This is the most uniform device we could achieve, which is the key to demonstrating artificial neural networks," says Kim.
The scientists then put the chip through its paces with a simulated test. They used an artificial neural network that functioned as though it was made up of three sheets of the neurons connected with two layers of the synapses. Then they fed in data on tens of thousands of handwriting samples, and found that the system was later able to recognize 95 percent of samples it was then given. That's not far off the 97 percent accuracy that more established systems can achieve.
Next, the team plans to develop a physical neuromorphic chip that can handle this task in the real world.
"Ultimately we want a chip as big as a fingernail to replace one big supercomputer," says Kim. "This opens a stepping stone to produce real artificial hardware."
The research was published in the journal Nature Materials.
Source: MIT, NewAtlas